# denote co-first authorship, * denote co-corresponding/co-senior authorship.



41. Xia Y, Shi Y, Chu J, Zhu S, Luo X, Shen W, Chen X: Efficient Biosynthesis of Acidic/Lactonic Sophorolipids and Their Application in the Remediation of Cyanobacterial Harmful Algal Blooms. International Journal of Molecular Sciences 2023, 24(15).

40. Wu Y, Deng J, Zheng Z, Chen N, Luo X*, Tang H*: Engineering an Efficient Expression Using Heterologous GAL Promoters and Transcriptional Activators in Saccharomyces cerevisiae. ACS Synthetic Biology 2023, 12(6):1859-1867.

39. Zhao X, Wu Y, Feng T, Shen J, Lu H, Zhang Y, Chou HH, Luo X, Keasling JD: Dynamic upregulation of the rate-limiting enzyme for valerolactam biosynthesis in Corynebacterium glutamicum. Metabolic Engineering 2023, 77:89-99.

38. Chen N, Yang S, You D, Shen J, Ruan B, Wu M, Zhang J, Luo X, Tang H: Systematic genetic modifications of cell wall biosynthesis enhanced the secretion and surface-display of polysaccharide degrading enzymes in Saccharomyces cerevisiae. Metabolic Engineering 2023, 77:273-282.

37. Li F, Deng H, Zhong B, Ruan B, Zhao X, Luo X: Identification of an indole biodegradation gene cluster from Providencia rettgeri and its contribution in selectively biosynthesizing Tyrian purple. Frontiers in bioengineering and biotechnology 2023, 10.


36.  Yu, H., Luo, X.*, IPPF-FE: an integrated peptide and protein function prediction framework based on fused features and ensemble models, Briefings in Bioinformatics, 2022;, bbac476,

35. Zhang, H., Liao, G., Luo, X.*, Tang, X.* (2022). Harnessing nature’s biosynthetic capacity to facilitate total synthesis. National Science Review.

34. Wu, D., Zhang, Y., Tang, Z., Chen, X., Ling, X., Li, L., Chao, W., Zheng, W., Tang, H., Liu, X., Luo, X.*, Liu, T.* (2022). Creation of a Yeast Strain with Co‐Translationally Acylated Nucleosomes. Angewandte Chemie, 134(30), e202205570.

33. Tang, H., Zhang, P., Luo, X. 2022. Recent Technologies for Genetic Code Expansion and their Implications on Synthetic Biology Applications. Journal of Molecular Biology, 434(8), 167382.

32. Xiao, R., Zhao, L., Ma, H., Liu, Q., Qin, H., Luo, X., Xuan, W. 2022. Toward an Orthogonal Protein Lysine Acylation and Deacylation System. ChemBioChem, 23(4), e202100551.

31. Wang, X., Luo, X. 2022. Precursor Quantitation Methods for Next Generation Food Production. Frontiers in Bioengineering and Biotechnology, 10.

30. Tang, H., Zhang, P., Luo, X. 2022. Recent Technologies for Genetic Code Expansion and their Implications on Synthetic Biology Applications. Journal of Molecular Biology, 434(8), 167382.


29. Xiao, R., Zhao, L., Ma, H., Liu, Q., Qin, H., Luo, X. and Xuan, W., 2021. Toward an Orthogonal Protein Lysine Acylation and Deacylation System. ChemBioChem, p.e202100551.

28. Deng, J., Wu, Y., Zheng, Z., Chen, N., Luo, X., Tang, H. and Keasling, J.D., 2021. A synthetic promoter system for well-controlled protein expression with different carbon sources in Saccharomyces cerevisiae. Microbial cell factories, 20(1), pp.1-10.

27. Tang, H., Zhang, P. and Luo, X., 2021. Recent Technologies for Genetic Code Expansion and their Implications on Synthetic Biology Applications. Journal of molecular biology, p.167382.

26. Xia, Y., Li, X., Yang, L., Luo, X., Shen, W., Cao, Y., Peplowski, L. and Chen, X., 2021. Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol. Applied microbiology and biotechnology, 105(19), pp.7309-7319.

25. Zhang, Y., Zhou, L., Xia, J., Dong, C. and Luo, X., 2021. Human microbiome and its medical applications. Frontiers in molecular biosciences, p.1217.

24. Wang, Y., Chen, X., Cai, W., Tan, L., Yu, Y., Han, B., Li, Y., Xie, Y., Su, Y., Luo, X. and Liu, T., 2021. Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols. Angewandte Chemie, 133(18), pp.10128-10136.

23. Hu, R.#, Zhang, S.#, Meng, H., Yu, H., Zhang, J., Luo, X., Si, T.*, Liu,* C., Qiao,* Y. 2020. Machine learning for synthetic biology: Methods and applications Chinese Science Bulletin, 2020, 66(3), 284-299 (in Chinese)

22. Zhang, Y., He, D., Lu, H., Huang, J., Luo, X. 2020. Metabolic engineering of Saccharomyces cerevisiae chassis, Chinese Science Bulletin, 2020, 66(3), 310-318 (in Chinese)

21. Tang, H., Wu, Y., Deng, J., Chen, N., Zheng, Z., Wei, Y., Luo, X. and Keasling, J.D., 2020. Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae. Metabolites, 10(8), p.320.


Before SIAT

20. Luo, X.#; Reiter, M.A.#; d’Espaux, L.; Wong, J.; Denby, C.M.; Lechner, A.; Zhang, Y.; Grzybowski, A.T.; Harth, S.; Lin, W.; Lee, H.; Yu, C.; Shin, J.; Deng, K.; Benites, V.T.; Wang, G.; Baidoo, E.E.K.; Chen, Y.; Dev, I.; Petzold, C.J.; Keasling, J.D. “Complete biosynthesis of cannabinoids and their unnatural analogues in yeast”, Nature,2019, 567, 123. 

19. Supekova, L.; Zambaldo, C.; Choi, S.; Lim, R.; Luo, X.; Kazane, S.A.; Young, T.S.; Schultz, P.G. “The genetic incorporation of p-azidomethyl-l phenylalanine into proteins in yeast”, Bioorg. Med. Chem. Lett. 2018, 28, 1570

18. Yang, P.-Y.; Zou, H.; Lee, C.; Muppidi, A.; Chao, E.; Fu, Q.; Luo, X.; Wang, D.; Schultz, P.G.; Shen, W. “A Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate-Induced Mouse Colitis Models”, J. Med. Chem., 2018, 61, 3218.

17. Du, J.; Cao, Y.; Liu, Y.; Wang, Y.; Zhang, Y.; Fu, G.; Zhang, Y.; Lu, L.; Luo, X.; Kim, C.H.; Schultz, P.G.; Wang. F. “Engineering Bifunctional Antibodies with Constant Region Fusion Architectures”, J. Am. Chem. Soc., 2017, 139, 18607

16. Zambaldo, C.; Luo, X.; Mehta, A.P.; Schultz, P.G. “Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids”, J. Am. Chem. Soc. 2017, 139, 11646.

15. Luo, X.; Fu, G.; Wang, R.E.; Zhu, X.; Zambaldo, C.; Liu, R.; Liu, T.; Lyu, X.; Du, J.; Xuan, W.; Yao, A.; Reed, S.A.;Kang, M.; Zhang, Y.; Guo, H.; Huang, C.; Yang, P.-Y.; Wilson, I.A.; Schultz, P.G.; Wang, F. “Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria”, Nat. Chem. Biol. 2017, 13, 845.

14. Liu, T.; Jia, P.; Ma, H.; Reed, S.A.; Luo, X.; Larman, H.B.; Schultz, P.G. “Construction and Screening of a Lentiviral Secretome Library”, Cell. Chem. Biol. 2017, 24, 767.

13. Wang, R.E.; Wang, Y.; Zhang, Y.; Gabrelow, C.; Zhang, Y.; Chi, V.; Fu, Q.; Luo, X.; Wang, D.; Joseph, S.; Johnson, K.; Chatterjee, A.K.; Wright, T.M.; Nguyen-Tran, V.T.B.; Teijaro, J.; Theofilopoulos, A.N.; Schultz, P.G.; Wang, F. “Rational design of a Kv1. 3 channel-blocking antibody as a selective immunosuppressant”, Proc.Nat. Acad. Sci. 2016, 113, 11501.

12. Luo, X.*; Wang, T.-S.A*; Zhang, Y.; Wang, F.; Schultz, P. G. “Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator”, Cell. Chem. Biol., 2016, 23, 1098. *Authors contributed equally

11. Xuan, W.; Li, J.; Luo, X.; Schultz, P.G. “Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins”, Angew. Chem. Int. Ed. 2016, 128, 10219.

10. Liu, T.; Wang, Y.; Luo, X.; Li, J.; Reed, S.A.; Xiao, H.; Young, T.S.; Schultz, P.G. “Enhancing protein stability with extended disulfide bonds” Proc. Nat. Acad. Sci. 2016, 113, 5910.

9. Cao, Y.; Rodgers, D.T.; Du, J.; Ahmad, I.; Hampton, E.N.; Ma, J.S.Y; Mazagova, M.; Choi, S.-H.; Yun, H.Y.; Xiao, H.; Yang, P.; Luo, X.; Lim, R.K.V.; Pugh, H.M.; Wang, F.; Kazane, S.A.; Wright, T.M.; Kim, C.H.; Schultz, P.G.; Young, T.S. “Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer”, Angew. Chem. Int. Ed. 2016, 128, 7646.

8. Yang, P.-Y.; Zou, H.; Chao, E.; Sherwood, L.; Nunez, V.; Keeney, M.; Ghartey-Tagoe, E.; Ding, Z.; Quirino, H.; Luo, X.; Welzel, G.; Chen, G.; Singh, P.; Woods, A.K.; Schultz, P.G.; Shen, W. “Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery”, Proc. Nat. Acad. Sci. 2016, 113, 4140.

7. Luo, X.; Zambaldo, C.; Liu, T.; Zhang, Y.; Xuan, W.; Wang, C.; Reed, S.A.; Yang, P.Y.; Wang, R.E.; Javahishvili, T.; Schultz, P. G.; Young, T.S. “Recombinant Thiopeptides with Noncanonical Amino Acids”, Proc. Nat. Acad. Sci.2016, 113, 3615.

6. Luo, X.*; Liu, T.*; Wang, Y.; Jia, H.; Zhang, Y.; Caballero, D.; Du, J.; Wang, R. E.; Wang, D.; Schultz, P. G.; Wang, F. “An Epitope-Specific Respiratory Syncytial Virus Vaccine based on an Antibody Scaffold”, Angew. Chem. Int. Ed. 2015, 54, 1. *Authors contributed equally

5. Harbut, M. B.; Vilchèze, C.; Luo, X.; Hensler, M. E.; Guo, H.; Yang, B.; Chatterjee, A. K.; Nizet, V.; Jacobs, W. R.; Schultz, P. G. “Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis”, Proc. Nat. Acad. Sci. 2015, 112, 4453.

4. Liu, T.; Du, J.; Luo, X.; Schultz, P. G.; Wang, F. “Homogeneously modified immunoglobulin domains for therapeutic application”, Curr. Opin. Chem. Biol. 2015, 28, 66.

3. Liu, T.; Fu, G.; Luo, X.; Liu, Y.; Wang, Y.; Wang, R. E.; Schultz, P. G.; Wang, F. “Rational Design of Antibody Protease Inhibitors”, J. Am. Chem. Soc. 2015, 137, 4042.

2. Wang, R. E.; Liu, T.; Wang, Y.; Cao, Y.; Du, J.; Luo, X.; Deshmukh, V.; Kim, C. H.; Lawson, B. R.; Tremblay, M. S.;Young, T.S.; Kazane, S.A.; Wang, F.; Schultz, P.G. “An Immunosuppressive Antibody–Drug Conjugate”, J. Am. Chem. Soc. 2015, 137, 3229.

1. Liu, T.; Zhang, Y.; Liu, Y.; Wang, Y.; Jia, H.; Kang, M.; Luo, X.; Caballero, D.; Gonzalez, J.; Sherwood, L.; Nunez,V.; Wang, D.; Woods, A.; Schultz, P.G.; Wang, F. “Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists”, Proc. Nat. Acad. Sci. 2015, 112, 1356.



3. Keasling, Jay D., Leo D’espaux, Jeff Wong, L. U. O. Xiaozhou, Michael Reiter, Charles Denby, and Anna Lechner. “Methods for producing cannabinoids and cannabinoid derivatives.” U.S. Patent 10,975,379, issued April 13, 2021.

2. Keasling, J.D.; Luo, X. Microorganisms and methods for producing meroterpenoids. U.S. Provisional Patent,2017

1. Wang, F., Schultz, P.G., Luo, X.; Liu, T. Antigenic Fusion Proteins and Methods of Vaccination. U.S. Patent pending, 2015