Publications

# denote co-first authorship, * denote co-corresponding/co-senior authorship.


At SIAT

2024

Wang, Xinran#, Chen, Ningxin#, Cruz-Morales, Pablo#, Zhong, Biming, Zhang, Yangming, Wang, Jian, Xiao, Yifan, Fu, Xinnan, Lin, Yang, Acharya, Suneil, Li, Zhibo, Deng, Huaxiang, Sun, Yuhui, Bai, Linquan, Tang, Xiaoyu*, Keasling, Jay D.*, & Luo, Xiaozhou*. (2024). Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis. Nature Metabolism. doi:10.1038/s42255-024-01024-9

Deng, Huaxiang#, Yu, Han#, Deng, Yanwu, Qiu, Yulan, Li, Feifei, Wang, Xinran, He, Jiahui, Liang, Weiyue, Lan, Yunquan, Qiao, Longjiang, Zhang, Zhiyu, Zhang, Yunfeng, Keasling, Jay D.*, & Luo, Xiaozhou*. (2024). Pathway Evolution Through a Bottlenecking-Debottlenecking Strategy and Machine Learning-Aided Flux Balancing. Advanced Science, 11(14), 2306935. doi:https://doi.org/10.1002/advs.202306935

2023

 Yu, Han#, Deng, Huaxiang#, He, Jiahui, Keasling, Jay D., & Luo, Xiaozhou*. (2023). UniKP: a unified framework for the prediction of enzyme kinetic parameters. Nature Communications, 14(1), 8211. doi:10.1038/s41467-023-44113-1

 

 Li, Feifei, Chen, Que, Deng, Huaxiang, Ye, Shumei, Chen, Ruidong, Keasling, Jay D., & Luo, Xiaozhou*. (2023). One-pot selective biosynthesis of Tyrian purple in Escherichia coli. Metabolic engineering. doi:10.1016/j.ymben.2023.11.003

Tang, Hongting#*, Lin, Shumin#, Deng, Jiliang#, Keasling, Jay D*, & Luo, Xiaozhou*. (2023). Engineering yeast for the de novo synthesis of jasmonates. Nature Synthesis, 1-12. 

Zhang, Yunfeng, Guo, Jiulong, Gao, PeiZhen, Yan, Wei, Shen, Junfeng, Luo, Xiaozhou*, & Keasling, Jay D*. (2023). Development of an efficient yeast platform for cannabigerolic acid biosynthesis. Metabolic engineering, 80, 232-240. doi:10.1016/j.ymben.2023.10.004

Wu, Yanling#, Deng, Jiliang#, Zheng, Zhaohui, Chen, Nanzhu, Luo, Xiaozhou*, & Tang, Hongting*. (2023). Engineering an Efficient Expression Using Heterologous GAL Promoters and Transcriptional Activators in Saccharomyces cerevisiae. Acs Synthetic Biology, 12(6), 1859-1867. doi:10.1021/acssynbio.3c00243

Zhao, Xixi, Wu, Yanling, Feng, Tingye, Shen, Junfeng, Lu, Huan, Zhang, Yunfeng, Chou, Howard H., Luo, Xiaozhou, & Keasling, Jay D. (2023). Dynamic upregulation of the rate-limiting enzyme for valerolactam biosynthesis in Corynebacterium glutamicum. Metabolic Engineering, 77, 89-99. doi:10.1016/j.ymben.2023.02.005

Chen, Nanzhu, Yang, Shuo, You, Dawei, Shen, Junfeng, Ruan, Banlai, Wu, Mei, Zhang, Jianzhi, Luo, Xiaozhou*, & Tang, Hongting*. (2023). Systematic genetic modifications of cell wall biosynthesis enhanced the secretion and surface-display of polysaccharide degrading enzymes in Saccharomyces cerevisiae. Metabolic Engineering, 77, 273-282. doi:10.1016/j.ymben.2023.04.011

Li, Feifei, Deng, Huaxiang, Zhong, Biming, Ruan, Banlai, Zhao, Xixi*, & Luo, Xiaozhou*. (2023). Identification of an indole biodegradation gene cluster from Providencia rettgeri and its contribution in selectively biosynthesizing Tyrian purple. Frontiers in Bioengineering and Biotechnology, 10. doi:10.3389/fbioe.2022.1109929

Xia, Yuanyuan, Shi, Yibo, Chu, Jieyu, Zhu, Shiying, Luo, Xiaozhou, Shen, Wei, & Chen, Xianzhong. (2023). Efficient Biosynthesis of Acidic/Lactonic Sophorolipids and Their Application in the Remediation of Cyanobacterial Harmful Algal Blooms. International Journal of Molecular Sciences, 24(15). doi:10.3390/ijms241512389

Yu, Han, & Luo, Xiaozhou. (2023). IPPF-FE: an integrated peptide and protein function prediction framework based on fused features and ensemble models. Briefings in Bioinformatics, 24(1). doi:10.1093/bibibbac476

2022

Zhang, Haili, Liao, Ge, Luo, Xiaozhou*, & Tang, Xiaoyu*. (2022). Special Topic: Natural Products and Drug Discovery Harnessing nature’s biosynthetic capacity to facilitate total synthesis. National Science Review, 9(11). doi:10.1093/nsr/nwac178

Wu, Dan, Zhang, Yunfeng, Tang, Zhiheng, Chen, Xiaoxu, Ling, Xinyu, Li, Longtu, Cao, Wenbing, Zheng, Wei, Wu, Jiale, Tang, Hongting, Liu, Xiaoyun, Luo, Xiaozhou*, & Liu, Tao*. (2022). Creation of a Yeast Strain with Co-Translationally Acylated Nucleosomes. Angewandte Chemie-International Edition, 61(30). doi:10.1002/anie.202205570

Tang, Hongting, Zhang, Pan, & Luo, Xiaozhou. (2022). Recent Technologies for Genetic Code Expansion and their Implications on Synthetic Biology Applications. Journal of Molecular Biology, 434(8). doi:10.1016/j.jmb.2021.167382

Xiao, Ruotong, Zhao, Lei, Ma, Hongpeng, Liu, Qiaoli, Qin, Hongqiang, Luo, Xiaozhou, & Xuan, Weimin. (2022). Toward an Orthogonal Protein Lysine Acylation and Deacylation System. Chembiochem, 23(4). doi:10.1002/cbic.202100551

Wang, Xinran, & Luo, Xiaozhou. (2022). Precursor Quantitation Methods for Next Generation Food Production. Frontiers in Bioengineering and Biotechnology, 10. doi:10.3389/fbioe.2022.849177 

Zhang, Yangming, Zhou, Linguang, Xia, Jialin, Dong, Ce, & Luo, Xiaozhou. (2022). Human microbiome and its medical applications. Frontiers in Molecular Biosciences, 8, 703585. 

2021

Deng, Jiliang, Wu, Yanling, Zheng, Zhaohui, Chen, Nanzhu, Luo, Xiaozhou, Tang, Hongting, & Keasling, Jay D. (2021). A synthetic promoter system for well-controlled protein expression with different carbon sources in Saccharomyces cerevisiae. Microbial Cell Factories, 20(1). doi:10.1186/s12934-021-01691-3

Xia, Yuanyuan, Li, Xiaoyu, Yang, Linli, Luo, Xiaozhou, Shen, Wei, Cao, Yu, Peplowski, Lukasz, & Chen, Xianzhong. (2021). Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol. Applied Microbiology and Biotechnology, 105(19), 7309-7319. doi:10.1007/s00253-021-11551-0

Wang, Yong, Chen, Xiaoxu, Cai, Wenkang, Tan, Linzhi, Yu, Yutong, Han, Boyang, Li, Yuxuan, Xie, Yuanzhe, Su, Yeyu, Luo, Xiaozhou, & Liu, Tao. (2021). Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols. Angewandte Chemie-International Edition, 60(18), 10040-10048. doi:10.1002/anie.202014540


2020
Hu, Runyun#, Zhang, Songya#, Meng, Hailin, Yu, Han, Zhang, Jianzhi, Luo, Xiaozhou, Si, Tong*, Liu, Chenli*, Qiao, Yu*. (2020). Machine learning for                       synthetic biology: Methods and applications. Chinese Science Bulletin, 66(3), 284-299. (in Chinese)

Zhang, Yunfeng, He, Dan, Lu, H., Huang, J., Luo, Xiaozhou(2020). Metabolic engineering of Saccharomyces cerevisiae chassis. Chinese Science Bulletin,               66(3), 310-318. (in Chinese)

Tang, Hongting, Wu, Yanling, Deng, Jiliang, Chen, Nanzhu, Zheng, Zhaohui, Wei, Yongjun, Luo, Xiaozhou, & Keasling, Jay D. (2020). Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae. Metabolites, 10(8). doi:10.3390/metabo10080320

 

Before SIAT

2019

Luo, Xiaozhou#, Reiter, Michael A.#, d’Espaux, Leo, Wong, Jeff, Denby, Charles M., Lechner, Anna, Zhang, Yunfeng, Grzybowski, Adrian T., Harth, Simon, Lin, Weiyin, Lee, Hyunsu, Yu, Changhua, Shin, John, Deng, Kai, Benites, Veronica T., Wang, George, Baidoo, Edward E. K., Chen, Yan, Dev, Ishaan, Petzold, Christopher J., & Keasling, Jay D. (2019). Complete biosynthesis of cannabinoids and their unnatural analogues in yeast. Nature, 567(7746), 123-+. doi:10.1038/s41586-019-0978-9

2018

Supekova, Lubica, Zambaldo, Claudio, Cho, Seihyun, Lim, Reyna, Luo, Xiaozhou, Kazane, Stephanie A., Young, Travis S., & Schultz, Peter G. (2018). The genetic incorporation of p-azidomethyl-L-phenylalanine into proteins in yeast. Bioorganic & Medicinal Chemistry Letters, 28(9), 1570-1573. doi:10.1016/j.bmcl.2018.03.055

Yang, Peng-Yu, Zou, Huafei, Lee, Candy, Muppidi, Avinash, Chao, Elizabeth, Fu, Qiangwei, Luo, Xiaozhou, Wang, Danling, Schultz, Peter G., & Shen, Weijun. (2018). Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models. Journal of Medicinal Chemistry, 61(7), 3218-3223. doi:10.1021/acs.jmedchem.7b00768

2017

Liu, Tao, Jia, Panpan, Ma, Huailei, Reed, Sean A., Luo, Xiaozhou, Larman, H. Benjamin, & Schultz, Peter G. (2017). Construction and Screening of a Lentiviral Secretome Library. Cell Chemical Biology, 24(6), 767-+. doi:10.1016/j.chembiol.2017.05.017

Du, Juanjuan, Cao, Yu, Liu, Yan, Wang, Ying, Zhang, Yong, Fu, Guangsen, Zhang, Yuhan, Lu, Lucy, Luo, Xiaozhou, Kim, Chan Hyuk, Schultz, Peter G., & Wang, Feng. (2017). Engineering Bifunctional Antibodies with Constant Region Fusion Architectures. Journal of the American Chemical Society, 139(51), 18607-18615. doi:10.1021/jacs.7b09641

Zambaldo, Claudio, Luo, Xiaozhou, Mehta, Angad P., & Schultz, Peter G. (2017). Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids. Journal of the American Chemical Society, 139(34), 11646-11649. doi:10.1021/jacs.7b04159

Luo, Xiaozhou, Fu, Guangsen, Wang, Rongsheng E., Zhu, Xueyong, Zambaldo, Claudio, Liu, Renhe, Liu, Tao, Lyu, Xiaoxuan, Du, Jintang, Xuan, Weimin, Yao, Anzhi, Reed, Sean A., Kang, Mingchao, Zhang, Yuhan, Guo, Hui, Huang, Chunhui, Yang, Peng-Yu, Wilson, Ian A., Schultz, Peter G., & Wang, Feng. (2017). Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria. Nature Chemical Biology, 13(8), 845-+. doi:10.1038/nchembio.2405

2016

Luo, Xiaozhou#, Wang, Tsung-Shing Andrew#, Zhang, Yong, Wang, Feng, & Schultz, Peter G. (2016). Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator. Cell Chemical Biology, 23(9), 1098-1102. doi:10.1016/j.chembiol.2016.08.007

Wang, Rongsheng E., Wang, Ying, Zhang, Yuhan, Gabrelow, Chase, Zhang, Yong, Chi, Victor, Fu, Qiangwei, Luo, Xiaozhou, Wang, Danling, Joseph, Sean, Johnson, Kristen, Chatterjee, Arnab K., Wright, Timothy M., Nguyen-Tran, Van T. B., Teijaro, John, Theofilopoulos, Argyrios N., Schultz, Peter G., & Wang, Feng. (2016). Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant. Proceedings of the National Academy of Sciences of the United States of America, 113(41), 11501-11506. doi:10.1073/pnas.1612803113

Liu, Tao, Wang, Yan, Luo, Xiaozhou, Li, Jack, Reed, Sean A., Xiao, Han, Young, Travis S., & Schultz, Peter G. (2016). Enhancing protein stability with extended disulfide bonds. Proceedings of the National Academy of Sciences of the United States of America, 113(21), 5910-5915. doi:10.1073/pnas.1605363113

Luo, Xiaozhou, Zambaldo, Claudio, Liu, Tao, Zhang, Yuhan, Xuan, Weimin, Wang, Chen, Reed, Sean A., Yang, Peng-Yu, Wang, Rongsheng E., Javahishvili, Tsotne, Schultz, Peter G., & Young, Travis S. (2016). Recombinant thiopeptides containing noncanonical amino acids. Proceedings of the National Academy of Sciences of the United States of America, 113(13), 3615-3620. doi:10.1073/pnas.1602733113

Cao, Yu, Rodgers, David T., Du, Juanjuan, Ahmad, Insha, Hampton, Eric N., Ma, Jennifer S. Y., Mazagova, Magdalena, Choi, Sei-hyun, Yun, Hwa Young, Xiao, Han, Yang, Pengyu, Luo, Xiaozhou, Lim, Reyna K. V., Pugh, Holly M., Wang, Feng, Kazane, Stephanie A., Wright, Timothy M., Kim, Chan Hyuk, Schultz, Peter G., & Young, Travis S. (2016). Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer. Angewandte Chemie-International Edition, 55(26), 7520-7524. doi:10.1002/anie.201601902

Xuan, Weimin, Li, Jack, Luo, Xiaozhou, & Schultz, Peter G. (2016). Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins. Angewandte Chemie-International Edition, 55(34), 10065-10068. doi:10.1002/anie.201604891

Yang, Peng-Yu, Zou, Huafei, Chao, Elizabeth, Sherwood, Lance, Nunez, Vanessa, Keeney, Michael, Ghartey-Tagoe, Esi, Ding, Zhongli, Quirino, Herlinda, Luo, Xiaozhou, Welzel, Gus, Chen, Guohua, Singh, Parminder, Woods, Ashley K., Schultz, Peter G., & Shen, Weijun. (2016). Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery. Proceedings of the National Academy of Sciences of the United States of America, 113(15), 4140-4145. doi:10.1073/pnas.1601653113

2015

Liu, Tao, Du, Juanjuan, Luo, Xiaozhou, Schultz, Peter G., & Wang, Feng. (2015). Homogeneously modified immunoglobulin domains for therapeutic application. Current Opinion in Chemical Biology, 28, 66-74. doi:10.1016/j.cbpa.2015.06.007

Luo, Xiaozhou#, Liu, Tao#, Wang, Ying, Jia, Haiqun, Zhang, Yuhan, Caballero, Dawna, Du, Juanjuan, Wang, Rongsheng E., Wang, Danling, Schultz, Peter G., & Wang, Feng. (2015). An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold. Angewandte Chemie-International Edition, 54(48), 14531-14534. doi:10.1002/anie.201507928

Wang, Rongsheng E., Liu, Tao, Wang, Ying, Cao, Yu, Du, Jintang, Luo, Xiaozhou, Deshmukh, Vishal, Kim, Chan Hyuk, Lawson, Brian R., Tremblay, Matthew S., Young, Travis S., Kazane, Stephanie A., Wang, Feng, & Schultz, Peter G. (2015). An Immunosuppressive Antibody-Drug Conjugate. Journal of the American Chemical Society, 137(9), 3229-3232. doi:10.1021/jacs.5b00620

Liu, Tao, Zhang, Yong, Liu, Yan, Wang, Ying, Jia, Haiqun, Kang, Mingchao, Luo, Xiaozhou, Caballero, Dawna, Gonzalez, Jose, Sherwood, Lance, Nunez, Vanessa, Wang, Danling, Woods, Ashley, Schultz, Peter G., & Wang, Feng. (2015). Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists. Proceedings of the National Academy of Sciences of the United States of America, 112(5), 1356-1361. doi:10.1073/pnas.1423668112

Harbut, Michael B., Vilcheze, Catherine, Luo, Xiaozhou, Hensler, Mary E., Guo, Hui, Yang, Baiyuan, Chatterjee, Arnab K., Nizet, Victor, Jacobs, William R., Jr., Schultz, Peter G., & Wang, Feng. (2015). Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4453-4458. doi:10.1073/pnas.1504022112

Liu, Tao, Fu, Guangsen, Luo, Xiaozhou, Liu, Yan, Wang, Ying, Wang, Rongsheng E., Schultz, Peter G., & Wang, Feng. (2015). Rational Design of Antibody Protease Inhibitors. Journal of the American Chemical Society, 137(12), 4042-4045. doi:10.1021/ja5130786

 

Patents

3. Keasling, Jay D., Leo D’espaux, Jeff Wong, L. U. O. Xiaozhou, Michael Reiter, Charles Denby, and Anna Lechner. “Methods for producing cannabinoids and cannabinoid derivatives.” U.S. Patent 10,975,379, issued April 13, 2021.

2. Keasling, J.D.; Luo, X. Microorganisms and methods for producing meroterpenoids. U.S. Provisional Patent, 2017

1. Wang, F., Schultz, P.G., Luo, X.; Liu, T. Antigenic Fusion Proteins and Methods of Vaccination. U.S. Patent pending, 2015